3,4 For glutathione to have these desirable effects, it needs certain molecular helpers, called cofactors, that facilitate its function
In: Coulston AM, Boushey CJ, Ferruzzi MG, editors
J., Brambilla, D
Paracetamol (acetaminophen) can deplete glutathione, leading to potentially fatal hepatotoxicity, especially in individuals with low baseline intrahepatic glutathione status, including those with HIV, chronic hepatitis C, cystic fibrosis, malnutrition, and anorexia nervosa (Kalsi 2011)
More studies are needed to explore this mechanism further, not least given the advent of medications targeting antioxidant systems which may be an important future therapeutic option in patients with MDD (Simon et al
121-123 Vitamin B12 and Other B-Complex Vitamins Vitamin B12 is needed for healthy function of nerves and blood vessels, and B12 deficiency can cause nerve damage resulting in a range of neurological symptoms, including tinnitus