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Only the l-stereoisomer participates in the biosynthesis of proteins

They see IV vitamin therapy as a luxury, not a necessity

Most studies are rodent models

One does need to increase the dosage slowly, titrating it, under monitoring TSH levels and most importantly, monitoring the patients well-being. Thyroid hormones in excess carry the risk of tachycardia and arrhythmia that is why usually the prohormone T4 and not the active hormone T3 is prescribed and supplemented

Oral supplements and topical creams are safer and more widely available than injections

There have been no large-scale, long-term studies to truly evaluate safety especially not for cancer risk