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Under normal conditions, NNMT activity can consume substantial amounts of both nicotinamide and SAM, particularly in metabolically active tissues or during periods of metabolic stress
Studies have shown that the peptide demonstrates approximately 40% oral bioavailability in animal models and exhibits rapid metabolism with a serum half-life of approximately 4 minutes, though its metabolic effects persist significantly longer due to downstream cellular activation
However, if you have a more severe B12 deficiency, you may require additional treatments to reach optimal levels
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The symptoms of pernicious anaemia all stem from a deficiency in Vitamin B12, which has a ripple effect across your entire body
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