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Supporting our cytochrome c assays, we confirmed no change in mitochondrial outer membrane permeabilization (MOMP) in cells surviving 5FU treatment (compared to the dimethyl sulfoxide group), and no increase in mitochondrial apoptotic priming based on BH3-profiling 15,16 induced by 5FU treatment (Extended Data Fig

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To investigate the transcriptional regulatory effect of Gln on the GGCT gene, a 2000-bp sequence of the GGCT gene promoter region was inserted into the pGL4-Basic vector