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The MS/MS fragmentation produced a diagnostic product ion at m/z 93, corresponding to the loss of CO 2 [(M H CO2) ]

A sore, red, or swollen tongue (glossitis)

Relative gene expression was calculated using the 2 -Ct method

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In early-stage cancer and precancerous lesions, decreased expression of GPX3 and increased ROS production promote cancer development

SCC or BCC expands as a precancerous lesion named actinic keratosis, which is also called keratinocyte intraepidermal neoplasia, very general in UV-exposed regions and looks like reddish macules which are further enfolded by yellowish scales