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Toremifene, which shares the stilbene scaffold with tamoxifen, is also likely to undergo aromatic ring hydroxylation to a catechol derivative (3,4-diOH metabolite), which could potentially lead to oxidative DNA damage

Epub 2016 Oct 5

Research suggests it may help improve skin elasticity, reduce inflammation and speed up wound healing

N.ChaturvediR

One example of NRF2 control of the redox balance in stem cells can be seen with peroxiredoxins 1 and 6 (PRDX1/6), which are critical reducers of intracellular hydrogen peroxide

However, these regimens have been plagued with long term drug toxicity leading to retarded neutrite growth, mitochondrial dysfunction, and oxidative stress 18