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NAD + is also involved in metabolic switching, or the Warburg effect, in which the main source of energy production is anaerobic glycolysis through fermentation of pyruvate to lactic acid, as opposed to mitochondrial oxidative phosphorylation 340

Studies have found that under physiological conditions, the GHK-Cu complex can form a binary or ternary structure, which includes the Cu-binding region of histidine and human albumin

The glucose metabolic reprogramming in CRC centers on the EMP-TCA cycle nexus, glucose uptake is facilitated initiated by glucose transporter 1 (GLUT1)-mediated glucose influx [13]

In addition, glutathione peroxidase enzymes help protect cell membranes from lipid peroxidation and maintain their integrity

& Sartor, G

doi: 10.1681/ASN.2012050457