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However, under pathophysiological conditions, especially during APAP overdose, excessive NAPQI accumulates and binds to cellular proteins, also triggering oxidative stress, leading to hepatocellular damage and the release of damage-associated molecular patterns (DAMPs), contributing to further liver injury and inflammation

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29 Many toxic heavy metals act as molecular mimics of nutritionally essential trace elements

Negatively charged targets are mainly represented by phospholipids, such as PS, which are secluded in the inner side of the plasmatic membrane in normal cells, but increasing the content of PS and accordingly increasing the cancer cell's negative charge allows for the specificity of ACPs (176,177,178)

M., Stricks, W