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Conversely, in diseases driven by protein misfolding and toxic substance accumulation (such as certain neurodegenerative diseases and CKD, and PCOS), enhancing LONP1 activity demonstrates significant therapeutic value
Pharmacologic inhibition of poly (ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats
However, they come with their own set of side effects and the long-term effectiveness varies from person-to-person, especially if you are not addressing the underlying dysfunction
They can evaluate you, look at a blood sample, and determine whether you have a deficiency
