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The main difference is the route of administration

Peptides are often pitched as a natural alternative to modern medicine Andrea Steinbrenner, a consulting executive, said she became intrigued by peptides after hearing about their benefits for longevity, repair, anti-aging and energy, from an acquaintance who runs a clinic outside of San Diego

While systemic injection also delivers peptides to the brain via blood circulation, nasal delivery may provide more direct CNS access for some portion of the dose