The SURMOUNT-1 trial showed up to 20.9% body weight reduction with 15 mg tirzepatide over 72 weeks, compared to roughly 15% with semaglutide in the STEP trials
Clinical trials in dogs are limited
Unlike Sermorelin and CJC-1295, BPC-157 does not work through the growth hormone axis its proposed mechanisms involve tissue repair, angiogenesis (new blood vessel formation), modulation of inflammatory pathways, and effects on tendon, ligament, and muscle healing
By inhibiting NNMT, 5-Amino-1MQ reduces 1-MNA formation and alleviates the methyl sink, increasing SAM availability for other methylation reactions, while freeing nicotinamide for recycling through NAMPT toward NAD
B12 shots are also not recommended if you have a history of issues like leukemia, myeloma, or certain types of anemia not caused by B12 deficiency
A combined approach may be considered depending on your goals and health needs