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Others may not be comfortable with their appearance and may use makeup, self-tanner, or skin dye to cover light patches

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Unfortunately, this initial phase often converts toxins into highly reactive intermediate metabolites that are actually more dangerous and damaging than the original substance

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However, Tregs can also adopt an inflammatory effector-like phenotype and lose their suppressive capacity due to chronic inflammation, metabolic reprogramming, tissue-specific reprogramming, and possibly insufficient IL-2 signaling 113,114