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doi: 10.1523/JNEUROSCI.1542-12.2012 75 HattersD

When AT-II production increases above normal levels, it induces vascular remodeling and endothelial dysfunction in association with increases in the levels of blood pressure

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Increased mitochondrial biogenesis improves muscle oxidative capacity, promoting ATP production through oxidative phosphorylation and optimizing the use of glucose and fatty acids as fuel