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J Clin Invest (2012) 122(8):294054

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2 , e1600200 (2016)

Suspension nasal sprays require all of the same device performance tests as solution sprays, plus drug particle size distribution (DPSD) by cascade impactor because it is the drug particle size (not the droplet size) that determines absorption rate in the nasal mucosa for suspensions

The effect was investigated on two thyroid cancer cell lines, 8505C (anaplastic thyroid cancer) and BCPAP (papillary thyroid cancer) and dual inhibition of BRAF and c-Met led to sustained treatment response