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When mitochondrial function is impaired, enzyme complex IV in the inner mitochondrial membrane fails to produce water as it should, resulting in the production of O 2 -, which subsequently convert into OH and H 2 O 2

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Tateishi, N., Higashi, T., Naruse, A., Nakashima, K

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What exists is a strong mechanistic foundation for both, a growing body of human clinical data for specific applications, and decades of clinical observation in functional medicine and medical aesthetics settings