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Dietary insufficiency is the primary cause among individuals following plant-based diets

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In addition, some investigators found that USP22 and lncRNA PART1 expression was decreased in a MIR injury model

A double-blind randomized controlled trial testing an antioxidant combination treatment (vitamin E, vitamin C, and -lipoic acid) in Alzheimers disease patients reported that this treatment was associated with accelerated cognitive decline as measured by the MMSE, despite a decrease in the level of oxidative stress (F2-isoprostane) in the cerebral spinal fluid (CSF) (19)

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