Additionally, cocaine induces apoptosis in cerebral vascular smooth muscle cells, contributing to vasoconstriction and ischemia, resulting in significant neurological damage ( 3.2 Neurological damage and psychiatric symptoms The neurological effects of cocaine include diffuse leukoencephalopathy, which is characterized by vasospasms, cerebral ischemia, and posterior reversible leukoencephalopathy (Rowbotham and Lowenstein, 1990
Lyophilized powder
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Chen et al., 2018
Subcutaneous administration (abdomen, thigh, deltoid) produces identical tissue concentrations at distant injury sites because the peptide travels through bloodstream and accumulates in areas undergoing active repair via concentration-gradient mechanisms
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