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Figure 3 Throughout our in vitro experiments, we exposed activated ILC2s to a pharmacological concentration (250M) of melatonin as has been shown previously to be maximally effective in driving phenotypic changes in T-cells without causing toxicity (43)

ROS can damage detrusor muscle mitochondria, resulting in decreased efficacy of energy production and impaired bladder contraction (183)

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Interestingly, differences in prooxidative parameters were more profound in acute coronary syndrome patients compared with coronary artery disease patients indicating that the acute form of coronary artery disease is more susceptible to oxidative damage, suggesting that use of antioxidant therapy may be warranted to reduce oxidative stress in this disorder (154)

Whether vitamin C enhances the ability of a bacterium to damage the protective chemicals found in the bladder wall