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B12 deficiency can also lead to the destruction of immature red blood cells in the bone marrow, which can cause jaundice (yellowing of the skin and whites of the eyes)

Thaw an aliquot only once when needed, and do not refreeze it after thawing3

Complementary mechanism without concerning interactions

The most common side effect of B12 injections is irritation at the injection site, and injections are typically administered intramuscularly or subcutaneously. Less common side effects may include headache, nausea, diarrhea, itching, or a brief feeling of lightheadedness after the injection