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doi: 10.1016/J.ENVRES.2020.109756 192

COX2: Cyclooxygenase 2

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It loses its structural integrity through oxidative damage and inadequate repair signaling

As a result, it was engineered for once-weekly dosing and has been studied both as standalone treatment and in fixed or given together combination with semaglutide, a GLP-1 receptor agonist