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The data indicated that more cells showed senescent phenotype in keloids

This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice

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Dose-response relationships in healthy young and middle-aged adults

What is RGN-352 and what were the clinical trial outcomes for TB-500/Thymosin Beta-4