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Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients

Cytosolic and nuclear NAD + are often considered a shared pool as NAD + diffuses through nuclear pores 58 , and importantly, the concentrations of NAD + in the cytosol, nucleus, and mitochondria mirror the K m of NAD + -consuming enzymes localized to the corresponding compartment, hence these enzymes are sensitive to compartmental fluctuations in NAD + levels 77

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American Journal of PhysiologyCell Physiology, 286(5), C1195C1202

We found that this phenomenon also holds true in human cells and we now show that NAC-induced roGFP2 oxidation is caused by sulfane sulfur species (hydropersulfides)