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The molecule's central position in glycolysis, gluconeogenesis, and fatty acid oxidation means that NAD+ availability directly influences metabolic flux and energy homeostasis

Nausea is the most frequently reported side effect, occurring in 20% to 47% of clinical trial participants depending on the dose

NNMTs role is to transfer a methyl group to nicotinamide (vitamin B3), creating 1-methylnicotinamide a reaction that consumes cellular methyl donors and depletes nicotinamide adenine dinucleotide (NAD) stores

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