There is no robust body of randomized controlled trial data demonstrating that lipotropic injections cause clinically significant fat loss beyond what the accompanying calorie restriction, activity changes, and clinical monitoring would have produced anyway
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Interestingly, the expression of PNPLA2 and PNPLA3 oppose one another, with expression of PNPLA2 highest during conditions that promote TAG hydrolysis such as fasting, while the expression of PNPLA3 is highest during conditions that promote TAG synthesis such as feeding (62, 63)
