Different clinical symptoms reported in individual patients with 5-oxoprolinase deficiency are renal stone formation, enterocolitis, mental retardation, neonatal hypoglycemia, microcytic anemia and microcephaly [4045]
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Longer telomeres are associated with delayed aging, improved cellular function, and increased lifespan
498 The ZnR/GPR39 is reduced in calcified aortic valves from patients with CAVD
Synemin is expressed in reactive astrocytes and Rosenthal fibers in Alexander disease
Among the neurotoxic mechanisms leading to neuronal death, a prominent role is played by the excessive stimulation of NMDA glutamatergic receptor and increased Ca 2+ influx
