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Biological biomolecules based on gene expression, epigenetic alterations, microRNA profiles, protein phosphorylation and cytokine signatures can contribute to the selection of subsets of these patients for specific natural agents, monitoring in vivo biological efficacy and potential synergistic (or antagonistic) interactions with medical therapies (223)

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A separate 2013 review in the peer-reviewed journal Alcoholism: Clinical and Experimental Research synthesizing how alcohol consistently reduces slow-wave sleep duration and disrupts the nighttime endocrine pulse pattern reaches the same conclusion across multiple study populations