Experimentally, the minimum retention time of any stage before the symptoms begin to further deteriorate for both treated and untreated patients can be presumed as 2.5 years for stages 1, 2, and 3
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Of interest, D-amino acid metabolism was the most prominent metabolic pathway in both co-metabolism and microbial metabolism, with a total of five involved metabolites, and was the most relevant pathway for CAG pathogenesis
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Evidence remains limited and more robust studies are required