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Description

Mechanistically, DOX stabilizes the copper importer SLC31A1 (CTR1) by inhibiting its proteasomal degradation and downregulating the copper efflux transporter ATPase Copper Transporting Beta (ATP7B), leading to a net increase in cellular copper [17, 76]

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Minoxidil has been the gold-standard topical treatment for androgenetic alopecia for over three decades

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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 30% by weight of the carbomer

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(Cu-GHK, lamin,Copper Gly-L-His-L-Lys)

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