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Our experience shows that after 24-48 hours at room temperature, a reconstituted peptide's efficacy can be severely compromised, leading to inconsistent and unreliable data

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Because it is so efficiently absorbed in the upper intestine via dipeptide channels, very little of the compound makes its way to the colon where the osmotic laxative effect occurs

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Water Res 85:244254 McAllister B, Gusella JF, Landwehrmeyer GB, Lee J-M, MacDonald ME, Orth M, Rosser AE, Williams NM, Holmans P, Jones L (2021) Timing and impact of psychiatric, cognitive, and motor abnormalities in Huntington disease

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The researchers concluded that AOD9604 displayed a very good safety and tolerability profile indistinguishable from placebo. Critically, zero serious adverse events were attributed to the peptide, and no participants withdrew due to treatment-related effects

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