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However, the critical limitation remains the near-total absence of rigorous human clinical trial data

The NIH Vitamin B12 Fact Sheet for Health Professionals notes that oral supplementation is appropriate for many patients who do not have intrinsic factor deficiency

Evidence Limits and Safety Considerations Peptide-related compounds can vary widely in available human evidence, safety data, purity standards, formulation, and regulatory status

doi:10.1038/ijir.2008.51

Its regenerative properties have been widely studied, showing remarkable benefits for healing muscles, tendons, ligaments, the gut, and even the brain

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