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doi: 10.1016/j.jid.2018.04.029 265 YangYLZhouCChenQShenSZLiJDWangXLet al

Notably, the upregulated metabolites were related primarily to glutathione metabolism, including key precursors for glutathione synthesis ( -glutamylcysteine and acetylcysteine), metabolites involved in glutathione catabolism and its byproducts (cysteinylglycine and Cys-Gly), and both oxidized and reduced forms of glutathione (GSSG and GSH) and glutathione disulfide