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In the body, the overwhelming majority of circulating IGF-1 is not free it is bound to a family of six IGFBPs that regulate its availability, transport, and clearance, and that generally restrain its biological activity

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For muscle building, training-day-only protocols (4-5 days weekly) produce equivalent results with 30-40% less peptide consumption compared to daily injection

Research Journal of Microbiology,2011, 6: 310-321.and roles in disease