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Acclimation to diverse environmental stresses caused by a suppression of cytosolic ascorbate peroxidase in tobacco BY-2 cells

H., Risser, J

Slower titration is worth considering if: Nausea persists beyond 2 weeks at your current dose You experience significant GI symptoms that interfere with daily function Your body aches or muscle pain are severe You are losing weight faster than 1 to 2 percent of body weight per week (too-rapid weight loss increases muscle loss risk) Some researchers use a 6 or 8-week interval between dose increases instead of the standard 4 weeks

References [i] Barkan, A

It might not work for severe injuries