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Understanding the specific effects reported helps set realistic expectations and allows for informed monitoring during treatment protocols

BMJ Open 10

This epithelial damage and subsequent unrestricted paracellular permeability has been observed in graft vs host disease and gastrointestinal conditions such as Crohn's disease and ulcerative colitis [39], and may play a role after acute cardiovascular events, such as after a stroke, where damage to intestinal epithelial cells is severe [40]

One important consideration is that only three published human clinical trials exist for BPC-157

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