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In every study, the growth factor was delivered by cannula to the putamen as the naked protein or as an AAV2 carrying c-DNA construct

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Serigano K, Sakai D, Hiyama A, Tamura F, Tanaka M, Mochida J: Effect of cell number on mesenchymal stem cell transplantation in a canine disc degeneration model

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In mouse models, ALLO appears to increase neurogenesis, reduce amyloid deposition and improve performance on learning and memory tests, suggesting that it may serve as a regenerative therapeutic (197, 277279)