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This suggests that levels of free heme alone are not sufficient to immediately change the oxidative state of the parasite, although it is recognised that chemical inhibition of cysteine proteases may have additional impacts on the parasite, and does not perfectly mimic the heme depletion caused by K13-mediated alteration of hemoglobin uptake
Cells were seeded in complete medium consisting of RPMI-1640 supplemented with 10% FCS (Sigma), 1% Penicillin/Streptomycin (GIBCO), 1% L-Glutamine (Sigma), and 55 mM -mercaptoethanol (GIBCO)
Human lens thioltransferase: cloning, purification, and function
The identified glutathione-related pathways provide potential therapeutic targets for alleviating oxidative stress-induced hippocampal injury in SAE, offering new insights for the clinical management of SAE-related neurological damage
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