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Stabilization of hypoxia-inducible factor-1 protein in hypoxia occurs independently of mitochondrial reactive oxygen species production

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Since Glutathione levels decline as we age, this has a particular effect on the immune systems of the older population

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On this occasion, the authors expand our understanding of glutathione biology and identify extracellular glutathione (GSH), abundant in the tumour microenvironment, as an alternative source of essential amino acids to sustain tumour cell proliferation