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Lower glutathione levels may be associated with fatigue, poor sleep, frequent infections, anaemia (low red blood cell counts) and poor coordination, and are most commonly seen in the elderly population
For these individuals, a conservative schedule extends each dose step to 6 weeks instead of 4, giving the body additional adaptation time
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To manage the risk of elevated transaminase levels, assess ALT and AST: within one month prior to initiation of XENPOZYME, within 72 hours prior to any infusion during dose escalation, which includes the first 3 mg/kg dose, or prior to the next scheduled XENPOZYME infusion upon resuming treatment following a missed dose
The Differences between GluN2A and GluN2B Signaling in the Brain