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Notably, AMPK activation by metformin or sustained TGF- signaling enhances Treg generation and facilitates Th17-to-Treg conversion, highlighting its role in immune tolerance (82, 83)

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doi: 10.2337/diabetes.51.4.1118

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Although the management of these complications is well-delineated in clinical guidelines based on robust interventional trial data and are major reasons for hospitalizations, certain symptoms significantly impacting quality of life often prompt recurrent outpatient and emergency visits among individuals with cirrhosis