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Subsequently, in a humidified dark chamber, the sections were incubated with primary anti-P53 (Rabbit Recombinant Monoclonal, ab32049, 1:50 dilution, Abcam) and anti-caspase-3 (Rabbit Polyclonal, ab4051, 1:100 dilution, Abcam) overnight at 4 C

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This work was supported by the grants from National Key R&D Program of China (2019YFA0802502), National Natural Science Foundation of China (81925008 and 32130047), Project supported by Shanghai Municipal Science and Technology Major Project, and Open Project Program of Metabolic Vascular Diseases Key Laboratory of Sichuan Province (2022MVDKL-K2) to YL