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Ultimately, a shift in redox state limits the ability to stay awake: intracerebroventricular infusion of oxidized glutathione into the brain increases time spent asleep [19,25]
& Hassanen, E
Cicero AFG, Allkanjari O, Busetto GM, et al
Lancet Neurol 18(5):459480 Feigin VL, Vos T, Nichols E, Owolabi MO, Carroll WM, Dichgans M et al (2024) Global, regional, and national burden of Parkinsons disease, 19902021: a systematic analysis for the Global Burden of Disease Study
Besides their role in mediating lipid peroxidation, ROS especially nitric oxide (NO ), and OH (92), have also been shown to attach to sperm DNA molecules causing excessive modifications and deletions in their nucleotide bases and strand breakages, along with other multiple genotoxic effects (93)
The exact mechanisms underlying this phenomenon are not known
