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Because you have huge amounts of pro-oxidants in your body

not all changes in the microbiome are harmful (some may be compensatory)

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Furthermore, in advanced liver fibrosis, the contractility of activated HSCs and myofibroblasts promotes liver sinusoidal contraction, affecting blood flow and nutrient exchange, exacerbating liver dysfunction

Importantly, with time the majority of relapse-onset patients will transition to a clinically progressive course [known as secondary progressive MS (SPMS)] characterized by cytodegeneration, while the inflammatory component wanes with age (Compston and Coles, 2008)

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