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Conversely, the VPA_RAT group showed higher species evenness, with elevated Shannon index (Figure S3D) and Simpson index (Figure S3E), indicating more balanced microbial distribution

however, current treatment methods, including surgery, chemotherapy, radiotherapy, targeted therapies, and immunotherapy, demonstrate limited success in effectively treating cancer [176]

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The efficacy of BRNPs in ROS overproducing tumors was better than that in ROS low-expressing tumors, which might be the limitation of BRNPs