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While 12 weeks of bright light exposure did not produce measurable improvements in sleep quality, glucose metabolism, or inflammatory markers, it significantly altered clock gene expression in peripheral blood mononuclear cells (PBMCs, specifically decreasing REV-ERB levels and increasing the REV-ERB/BMAL1 ratio)

Indeed, microglial activation leads to increased production of cytokines and activation of nitric oxide synthases (iNOS)

Yeo, S., Jang, J., Jung, H

Sahakian, L

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Source quality, dosing accuracy, and medical oversight are important