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The reasons: Receptor sensitivity: While GHK-Cu doesn't appear to cause receptor downregulation the way some peptides do, cycling is a general precaution to maintain responsiveness and avoid adaptations that might blunt benefits

[1] Peptides are potent epigenetic modulators: they alter DNA methylation, histone acetylation, and miRNA expression, directly changing which genes are active in your body

The pharmaceutical formulas developed by HT26 laboratories are tested and respect the epidermis

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10.1016/j.cryobiol.2020.03.008 7

doi:10.3389/fphar.2021.769501 Liu Y, Wang J, Wu C