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Non-enzymatic antioxidants, such as glutathione (GSH), play a critical role in detoxifying ROS

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Glutathione is a naturally occurring antioxidant present in the body's cells

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The copper concentration used in experiments critically influences cellular responses: low levels (0.10.1.2mmol/l) induce physiological/adaptive transcriptional changes, while higher levels (0.4-0.4.6mmol/l) trigger toxic, stress-related responses [24]