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One study demonstrated that apatinib inhibited the expression of GLS1, activated the GCN2/eIF2/ATF4 pathway, and promoted the expression of SLC1A5, thereby reprogramming Gln metabolism in NSCLC and weakening the response of tumor cells to apatinib (33)

Chini CCS, Zeidler JD, Kashyap S, Warner G, Chini EN

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These include injection site pain, headache, dizziness, and rarely, hypersensitivity reactions

Alpha-lipoic acid (ALA) is another important supplement