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Animal studies on diabetic rat models revealed decreased microvascular density in the testes, reduced blood perfusion, and significantly impaired sperm production [260]

In a further embodiment, the syringes disclosed herein comprise at least one reservoir wherein the at least one reservoir comprises an otic agent, or a pharmaceutically acceptable buffer, or a viscosity enhancing agent, or a combination thereof

GSH administration markedly decreased protein S-glutathionylation (Fig