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This is because psychoactive drug abuse triggers neuroadaptations in brain regions that are also involved in other psychiatric illnesses, such as anxiety, mood, or impulse-control disorders, and schizophrenia, according to a 2020 publication by the National Institutes on Drug Abuse , titled Common Comorbidities with Substance Use Disorders Research Report. Aggravation of the symptoms of a mental illness: Psychoactive substances are known to exacerbate the symptoms of a co-occurring mental illness by disrupting the normal and healthy functioning of the neural mechanisms associated with experiencing pleasure or reward, perceiving stress, and regulating impulses (SAMHSA, 2016)
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