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GR, a crucial enzyme of ASC-GSH cycle catalyzes the formation of a disulfide bond in glutathione disulfide to maintain a high cellular GSH/GSSG ratio

A 2-year randomized controlled trial with low-dose B-vitamin supplementation shows benefits on bone mineral density in adults with lower B12 status

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however, only female heterozygous mice were obtained because hemizygous male embryos died